Chemical Profiling of Hashish Resin and its Possible Role in Forensic Cases Involving Violence in Jazan, Saudi Arabia
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Abstract
Hashish resin is a narcotic prepared from a concentrated extract of cannabis flowers and leaves. It can cause confusion, anxiety, panic, paranoia, and even psychosis. This study's goal was to assess the hazards associated with abuse of hashish resin, its chemical composition and possible role in forensic cases involving violence in Jazan, Saudi Arabia. For this purpose, all forensic cases in Jazan, from January 2019 to December 2021 were retrospectively investigated. The data were collected from the OTARR electronic system using the data collecting form. Gas chromatography-mass spectrometry was used to analyze the chemical composition of seized hashish. The percentage of cases having positive results for hashish in fatal cases were 1, 2, and 5% and in crime cases these were 29, 26, and 31% in 2019, 2020, and 2021, respectively. Homicide and suicide were the major manners of death among fatalities involving hashish. More than one-third of the crimes were related to hashish use/abuse. Amphetamine and ethanol were most used drugs in combination with hashish. The average level of THC (the active compound in hashish) in crimes and fatalities was determined. The relationships between chemical composition of seized hashish, mental diseases and violence were investigated and discussed.
Keywords
Forensic science, Fatalities, crimes, hashish, Suicide, Homicide, Violence, Postmortem, THC level
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References
United Nations Office on Drugs and Crime (UNODC). World Drug Report 2019. Office for Official Publications of the United Nations; 2019 [cited 2022 Oct 27]. Available from: https://wdr.unodc.org/wdr2019/prelaunch/WDR19_Booklet_5_CANNABIS_HALLUCINOGENS.pdf
Di Forti M, Morgan C, Dazzan P, Pariante C, Mondelli V, Marques TR, Handley R, Luzi S, Russo M, Paparelli A, Butt A. High-potency cannabis and the risk of psychosis. B. J. Psych. 2009; 195(6): 488-91. DOI: https://doi.org/10.1192/bjp.bp.109.064220
Vindenes V, Strand DH, Kristoffersen L, Boix F, Mørland J. Has the intake of THC by cannabis users changed over the last decade? Evidence of increased exposure by analysis of blood THC concentrations in impaired drivers. Forensic Sci. Int. 2013;226(1-3):197-201. DOI: https://doi.org/10.1016/j.forsciint.2013.01.017
Dannon PN, Lowengrub K, Amiaz R, Grunhaus L, Kotler M. Comorbid cannabis use and panic disorder: short term and long term follow‐up study. Hum. Psychopharmacol. 2004;19(2):97-101. DOI: https://doi.org/10.1002/hup.560
C Crippa JA, Zuardi AW, Martín‐Santos R, Bhattacharyya S, Atakan Z, McGuire P, Fusar‐Poli P. Cannabis and anxiety: a critical review of the evidence. Hum. Psychopharmacol. 2009;24(7):515-23. DOI: https://doi.org/10.1002/hup.1048
Breijyeh Z, Jubeh B, Bufo SA, Karaman R, Scrano L. Cannabis: A Toxin-Producing Plant with Potential Therapeutic Uses. Toxins. 2021;13(2):117. DOI:https://doi.org/10.3390/toxins13020117
Frolli A, Ricci MC, Cavallaro A, Lombardi A, Pastorino GMG, Operto FF. Executive Functions and Cannabis Use in Adolescents. Acta Scientific Neurology. 2020;3:54-62. Available from: https://www.preprints.org/manuscript/202007.0499/v1
Sewell RA, Schnakenberg A, Elander J, Radhakrishnan R, Williams A, Skosnik PD, Pittman B, Ranganathan M, D’Souza DC. Acute effects of THC on time perception in frequent and infrequent cannabis users. Psychopharmacology. 2013;226(2):401-13. DOI: https://doi.org/10.1007/s00213-012-2915-6
Matte AC. Effects of hashish on isolation induced aggression in wild mice. Psychopharmacologia. 1975;45(1):125-8. DOI: https://doi.org/10.1007/BF00426221
Kouri EM, Pope Jr HG. Abstinence symptoms during withdrawal from chronic marijuana use. Exp. Clin. Psychopharmacol. 2000;8(4):483. DOI: https://doi.org/10.1037/1064-1297.8.4.483
Nahas GG, Sutin KM, Harvey DJ, Agurell S. Marihuana and Medicine: Humana Press; 1999.
Grenyer B, Solowij N, Barlow K. Cannabis use is associated with greater psychotic symptoms and increased potential risk of aggression. Paper presented at Inaugural International Cannabis and Psychosis Conference; 1999 Feb 5; Melbourne, Australia.
Nahas GG. Cannabis Physiopathology Epidemiology Detection: CRC Press; 1992.
Eksborg S, Rajs J. Causes and manners of death among users of heroin, methadone, amphetamine, and cannabis in relation to postmortem chemical tests for illegal drugs. Subst Use Misuse. 2008;43(10):1326-39. DOI: https://doi.org/10.1080/10826080801922124
Caligiani A, Palla G, Bernardelli B. GC‐MS analysis of hashish samples: a case of adulteration with colophony. J. Forensic Sci. 2006;51(5):1096-100. DOI: https://doi.org/10.1111/j.1556-4029.2006.00202.x
Bengyella L, Kuddus M, Mukherjee P, Fonmboh DJ, Kaminski JE. Global impact of trace non-essential heavy metal contaminants in industrial cannabis bioeconomy. Toxin Reviews. 2021:1-11. DOI: https://doi.org/10.1080/15569543.2021.1992444
Oomen PE, Schori D, Tögel-Lins K, Acreman D, Chenorhokian S, Luf A, Karden A, Paulos C, Fornero E, Gerace E, Koning RP. Cannabis adulterated with the synthetic cannabinoid receptor agonist MDMB-4en-PINACA and the role of European drug checking services. Int. J. Drug Policy. 2022;100:103493. DOI: https://doi.org/10.1016/j.drugpo.2021.103493
McPartland JM. Adulteration of cannabis with tobacco, calamus, and other cholinergic compounds. Cannabinoids. 2008;3(4):16-20. Available from: http://www.cannabis-med.org/english/journal/en_2008_04_2.pdf
Ritchie H, Roser M. Opioids, cocaine, cannabis and illicit drugs. Our World in Data. 2018 [cited 2022 October 27]. Available from: https://ourworldindata.org/illicit-drug-use
Youssef IM, Fahmy MT, Haggag WL, Mohamed KA, Baalash AA. Dual diagnosis and suicide probability in poly-drug users. J Coll Physicians Surg Pak. 2016;26(2):130-3. Available from: https://pubmed.ncbi.nlm.nih.gov/26876401/
Almarhabi Y, Mufti AI, Almaymuni AD, Abdurahman T, Abdulaziz G, Alghamdi AA, Moniem Mukhtar A. Substance abuse at early age as a potential risk factor for driving under the influence of substance in Jeddah, Saudi Arabia: a cross-sectional study. Traffic Inj. Prev. 2018;19(7):687-92. DOI: https://doi.org/10.1080/15389588.2018.1494828
Kuhns JB, Wilson DB, Maguire ER, Ainsworth SA, Clodfelter TA. A meta‐analysis of marijuana, cocaine and opiate toxicology study findings among homicide victims. Addiction. 2009;104(7):1122-31. DOI: https://doi.org/10.1111/j.1360-0443.2009.02583.x
Denissoff A, Niemelä S, Scott JG, Salom CL, Hielscher E, Miettunen J, Alakokkare AE, Mustonen A. Does cannabis use in adolescence predict self‐harm or suicide? Results from a Finnish Birth Cohort Study. Acta Psychiatr. Scand. 2022;145(3):234-43. DOI: https://doi.org/10.1111/acps.13384
Borges G, Bagge CL, Orozco R. A literature review and meta-analyses of cannabis use and suicidality. J. Affect. Disord. 2016;195:63-74. DOI: https://doi.org/10.1016/j.jad.2016.02.007
Moore TH, Zammit S, Lingford-Hughes A, Barnes TR, Jones PB, Burke M, Lewis G. Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review. The Lancet. 2007;370(9584):319-28. DOI: https://doi.org/10.1016/S0140-6736(07)61162-3
Mahmoud NF, Al-Mazroua MK, Afify MM, Issa SY. Forensic Toxicology Analysis of Suicidal Hanging Deaths in Eastern Province-Saudi Arabia. Indian J. Forensic Med. Toxicol. 2021;15(2). DOI: https://doi.org/10.37506/ijfmt.v15i2.14850
Meier MH. Cannabis use and psychosocial functioning: evidence from prospective longitudinal studies. Curr Opin Psychol. 2021;38:19-24.. DOI: https://doi.org/10.1016/j.copsyc.2020.07.001
Calabria B, Degenhardt L, Hall W, Lynskey M. Does cannabis use increase the risk of death? Systematic review of epidemiological evidence on adverse effects of cannabis use. Drug and alcohol review. 2010;29(3):318-30. DOI: https://doi.org/10.1111/j.1465-3362.2009.00149.x
Van Os J, Bak M, Hanssen M, Bijl R, De Graaf R, Verdoux H. Cannabis use and psychosis: a longitudinal population-based study. Am. J. Epidemiol. 2002;156(4):319-27. DOI: https://doi.org/10.1093/aje/kwf043
D’Souza DC, Perry E, MacDougall L, Ammerman Y, Cooper T, Wu YT, Braley G, Gueorguieva R, Krystal JH. The psychotomimetic effects of intravenous delta-9-tetrahydrocannabinol in healthy individuals: implications for psychosis. Neuropsychopharmacol. 2004;29(8):1558-72. DOI: https://doi.org/10.1038/sj.npp.1300496
Pettersen S, Øiestad ÅML, Rogde S, Brochmann G-W, Øiestad EL, Vindenes V. Distribution of tetrahydrocannabinol and cannabidiol in several different postmortem matrices. Forensic Sci. Int. 2021;329:111082. DOI: https://doi.org/10.1016/j.forsciint.2021.111082.
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