Carbon monoxide (CO) intoxication is the inhalation of concentration of CO that is above the tolerant competence of the body. The quantity of CO inhaled determined the extent of damage inflicted on the body system which could lead to immediate morbidity or mortality. The euphoric and rapidity of the mechanism of action attributed to CO ranked it as deleterious gas that could cause irreparable or reparable damage depending on the concentration, health and immunological capacity of the body. The rapidity is now employed by criminals in perpetrating homicide and disguising it as suicidal or suicidal. The discovery of the body resulting from such an incidence and the postmortem interval has made blood very inefficient in determining the presence of CO or other ancillary damage. This called for the use of vitreous humor that can stand putrefaction and autolysis for a longer period. The dilemma in discriminating death resulting truly from CO intoxication from that of disguised is the quest of this study. This review elaborately takes a critical look at literatures relating to the subject of discourse with the view of drawing silent points that could be of critical importance in forensic science. A thorough review of the picture of vitreous chemistry resulting from acute CO intoxication was almost exhaustively analyzed based on the very perspectives found in literatures and other documents of importance.
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