Anticoagulant rodenticides (AR) are among the most commonly
used rodent control pesticides. The current second-generation
rodenticides in worldwide use are referred to as superwarfarins.
These substances have relatively low toxicity to humans but significant
toxicity to animals, including pets.
AR work at the level of hepatocytes by blocking the synthesis
of plasma coagulation factors II, VII, IX, and X as well as proteins
C, S, and Z, resulting in severe coagulation disorders predominant
in the clinical picture.
Deaths associated with AR poisoning are the result of haemorrhages
into the gastrointestinal tract, peritoneal cavity, or intracranial
Medico-legal diagnosis of AR poisonings is based on the clinical
picture, autopsy, and histopathological and toxicological examinations.
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