Anticoagulant Rodenticides Poisonings in Humans and Animals – Short Review

Marcin Zawadzki, Paweł Szpot Szpot


Anticoagulant rodenticides (AR) are among the most commonly
used rodent control pesticides. The current second-generation
rodenticides in worldwide use are referred to as superwarfarins.
These substances have relatively low toxicity to humans but significant
toxicity to animals, including pets.
AR work at the level of hepatocytes by blocking the synthesis
of plasma coagulation factors II, VII, IX, and X as well as proteins
C, S, and Z, resulting in severe coagulation disorders predominant
in the clinical picture.
Deaths associated with AR poisoning are the result of haemorrhages
into the gastrointestinal tract, peritoneal cavity, or intracranial
Medico-legal diagnosis of AR poisonings is based on the clinical
picture, autopsy, and histopathological and toxicological examinations.


Forensic Science, Anticoagulants, Rodenticides, Poisoning, Humans.

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Navabi SM, Navabi J, Aghaei A, Shaahmadi Z, Heydari

R. Mortality from aluminum phosphide poisoning

in Kermanshah Province, Iran: characteristics and predictive

factors. Epidemiol health. 2018;40:e2018022-.

Bennett DL, Caravati EM, Veltri JC. Long-acting acticoagulant

injection: a prospective study. Vet Hum Toxiocol.


Zawadzki M, Magdalan J, Niedźwiedź A. Poisonings

with anticoagulant rodenticides. Arch Med Sad Krym.


Nicpoń J, Zawadzki M, Niedźwiedź A, Kubiak K,

Jankowski M, Magdalan J. Anticoagulant rodenticides

poisoning in dogs. Med Wet. 2007;63(12):1604-6

Laszkowska-Lewko M, Rybka J, Zawadzki M, Jurek

T, Wróbel T. Coagulation disorders caused by chronic

poisoning with anticoagulant rodenticides – case report

and review of literature. Hematol 2017;8(4):289-92.

Soubiron L, Hantson P, Michaux I, Lambert M, Mahieu

P, Pringot J. Spontaneous haemoperitoneum from surreptitious

of a rodenticide. Eur J Med. 2000;7:305-7.

Palmer RB, Alakija P, de Baca JE, Nolte KB. Fatal

brodifacoum rodenticide poisoning: autopsy and toxicology

findings. J Forensic Sci. 1999;44: 851-5. https://

Kruse JA, Carlson RW. Fatal rodenticide poisoning

with brodifacoum. Ann Emerg Med. 1992;21(3):331-6.

Olmos V, Lopez CM. Brodifacoum poisoning with toxicokinetic

data. Clin Toxicol (Phila). 2007;45(5):487-9.

Lo VM, Ching C, Chan AYW, Mak TWL. Bromadiolone

toxicokinetics: diagnosis and treatment implications.

Clin Toxicol (Phila). 2008;46(8):703-10. https://

Vindenes V, Karinen R, Hasvold I, Bernard JP, Morland

JG, Christophersen AS. Bromadiolone poisoning:

LC-MS method and pharmacokinetic data. J Forensic

Sci 2008; 53(4): 993-6.


Yan H, Xiang P, Zhu L, Shen M. Determination of bromadiolone

and brodifacoum in human blood using LCESI/

MS/MS and its application in four superwarfarin

poisoning cases. Forensic Sci Int. 2012;222(1-3):313-7.

Imran M, Shafi H, Wattoo SA, Chaudhary MT, Usman

HF. Analytical methods for determination of anticoagulant

rodenticides in biological samples. Forensic

Sci Int. 2015;253: 94-102.


Thomas PJ, Mineau P, Shore RF, Champoux L, Martin

PA, Wilson LK, Fitzgerald G, Elliott JE. Second generation

anticoagulant rodenticides in predatory birds:

Probabilistic characterization of toxic liver concentrations

and implications for predatory bird populations

in Canada. Environ Int. 2011;37:914-920. https://doi.


Lambert O, Pouliquen H, Larhantec M, Thorin C,

L’Hostis M. Exposure of raptors and waterbirds to

anticoagulant rodenticides (difenacoum, bromadiolone,

coumatetralyl, coumafen, brodifacoum): epidemiological

survey in Loire Atlantique (France). Bull

Environ Contam Toxicol. 2007;79:991-4. https://doi.


Babcock J, Hartman K, Pedersen A, Murphy M, Alving

B. Rodenticide-induced coagulopathy in a young

child. A case of Munchausen syndrome by proxy. Am

J Pediatr Hematol Oncol. 1993;15:126-30. https://doi.


Schulz M, Iwersen-Bergmann S, Andersen H, Schmoldt

A. Therapeutic and toxic blood concentrations of

nearly 1000 drugs and other xenobiotics. Crit Care.

;16(4): R136.



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